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Central Alabama is a region in the state of Alabama. It is sometimes considered part of North Alabama because both regions are mountainous, but in some definitions they are different regions.

The Valley and Ridge Province of the Appalachians consist mainly of long, low ridges such as Red Mountain, Sand Mountain, Beaver Creek Mountain, Shades Mountain, and Coldwater Mountain in this region, and make impressive backdrops in the Greater Birmingham, Gadsden, and Anniston metropolitan areas. The easternmost part of Central Alabama around Anniston has the steepest mountains and highest elevations of the region. Coldwater Mountain and Mount Cheaha make up the highest of the mountain ridges that are located in the eastern portion of the region. The Coosa River divides the easternmost portion of the region from the central portion with the Birmingham area. The westernmost portion of Central Alabama is relatively a flat region with fertile black soil called the Black Belt. The Black Warrior River and its tributaries contribute to the fertile land of the area, and also serve as a demarcation line between the western and the central portions of the region. The central portion of Central Alabama varies from rugged in the east to flat in the west. Numerous valleys are scattered throughout this region between the mountain ridges including the densely populated Jones Valley and Shades Valley. Because the central portion is more rugged compared to the westernmost portion of Central Alabama, it is also the most flood-prone. Urban sprawl has exacerbated the risk of flooding by increasing the proportion of land covered by hard surfaces, leading to greater runoff during storms.

The Black Warrior, Cahaba, and Coosa Rivers and their tributaries are among the many waterways that wind their way through the region. Other major waterways that run through the area include Choccolocco Creek, Shades Creek, and Little Cahaba River.

Large deposits of iron ore, limestone, and coal are chief among the plentiful mineral resources found in the region. The coincidence of these three in close proximity was a major incentive for the rapid development of industry in the Birmingham District after the American Civil War.